Anthony E. Redington, Alyn H. Morice's Acute and Chronic Cough (Lung Biology in Health and Disease, PDF

By Anthony E. Redington, Alyn H. Morice

ISBN-10: 0824759583

ISBN-13: 9780824759582

A entire evaluate of the medical and medical points of acute and persistent cough, this reference specializes in fresh advancements in our knowing of the molecular biology of putative cough receptors, the neural mechanisms occupied with the afferent and efferent limbs, the primary processing of the cough reflex, and peptides and different elements that can mediate or modulate the cough reflex. With chapters wriitenby said gurus within the box, this instruction manual covers present and capability healing brokers, a variety of methodologies to degree cough reflex sensitivity, and medical techniques for the review of continual cough in adults and youngsters.

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Additional info for Acute and Chronic Cough (Lung Biology in Health and Disease, Volume 205)

Sample text

It is also possible, therefore, that these metabolites originate outside the afferent nerve and open the channels after penetrating the neuronal membrane (80). Other lipids capable of activating TRPV1 include anandamide, characterized originally as a cannabinoid CB1 receptor agonist (31). Sensory afferents express both TRPV1 and CB1; activation of the latter induces the relaxation of nerves. The concentrations of anandamide necessary for CB1 activation are in a similar range to those required for TRPV1 activation, so that the consequence of anandamide action on sensory afferents may be complex (81–83).

In this chapter the classes of vagal afferent nerves innervating the airways and their role in regulating the cough reflex will be defined. Classification of Airway Afferent Nerve Subtypes Airway afferent nerve subtypes are abundant in the airway mucosa and in the airway wall and can be differentiated based on their physicochemical sensitivity, adaptation to sustained lung inflation, neurochemistry, origin, myelination, conduction velocity, and sites of termination in the airways (Fig. 1). The utility of each of these approaches for defining airway afferent nerve subtypes is limited in large part by the lack of specificity of the various characteristics studied (5–21).

J Physiol. 2003; 551(pt 2):433–446. 117. Shelhamer JH, Levine SJ, Wu T, Jacoby DB, Kaliner MA, Rennard SI. NIH conference. Airway inflammation. Ann Intern Med 1995; 123:288–304. 118. Holtzman MJ. Arachidonic acid metabolism in airway epithelial cells. Annu Rev Physiol 1992; 54:303–329. 119. Drazen JM, Israel E, O’Byrne PM. Treatment of asthma with drugs modifying the leukotriene pathway. N Engl J Med 1999; 340:197–206. 120. Harrison S, Geppetti P. Substance P. Int J Biochem Cell Biol 2001; 33: 555–576.

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Acute and Chronic Cough (Lung Biology in Health and Disease, Volume 205) by Anthony E. Redington, Alyn H. Morice


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